Oligonucleotide ni polimeri ya nucleic aside ifite gahunda yabugenewe yabugenewe, harimo antisense oligonucleotide (ASOs), siRNAs (RNAs yivanga rito), microRNAs, na aptamers.Oligonucleotide irashobora gukoreshwa muguhindura imvugo ya gene binyuze mubikorwa bitandukanye, harimo RNAi, kwangirika kwintego binyuze muri clavage ya RNase H, guhuza ibice, gukandamiza RNA, kode ya gene, no guhindura gahunda ya gen.

Hafi ya oligonucleotide (ASOs, siRNA, na microRNA) ivanga kugirango igere kuri gene mRNA cyangwa pre-mRNA ikoresheje guhuza ibice byuzuzanya, kandi mubyukuri irashobora guhitamo guhindura imvugo ya gene na proteine ​​iyo ari yo yose, harimo na benshi "badavura".Aptamers ifitanye isano ya poroteyine igenewe, isa nuburyo bwa gatatu bwa antibodies, ntabwo bikurikirana.Oligonucleotide nayo itanga izindi nyungu, zirimo uburyo bworoshye bwo gukora no gutegura, tekinike ngufi yiterambere, ningaruka zirambye.

Ugereranije na molekile ntoya ya inhibitor, gukoresha oligonucleotide nkibiyobyabwenge nuburyo bushya bushya.Ubushobozi bwa oligonucleotide muri genetics itomoye bwongereye ishyaka ryo kuvura kanseri, indwara z'umutima n'imitsi, n'indwara zidasanzwe.Icyemezo cya FDA giherutse kwemeza Givosiran, Lumasiran na Viltolarsen kizana RNAi, cyangwa imiti ishingiye kuri RNA, muburyo rusange bwo guteza imbere ibiyobyabwenge.